Füzik et al.
Structure of tick-borne encephalitis virus and its neutralization by a monoclonal antibody.
Nat. Commun. 2018; 9:436, DOI: 10.1038/s41467-018-02882-0
The study by Füzik et al. presents the cryo-EM structure of TBE virus virions in the presence and absence of the Fab fragment of the neutralizing antibody 19/1786 (which neutralizes multiple strains and has minimal cross-reactivity with other flaviviruses). The authors present a mechanism of action of the neutralizing antibody based on the structural results and imaging at low pH. The epitope of the antibody is focused on the E domain III, but also interacts with domains I and II and various mutations were prepared to study the interaction with various sites of the E-protein.