Global Health Cast – Dengue: a complex disease

Part 1 of the Global Health Cast on Dengue presented by Prof. Schmitt and Prof. Sáfadi. 00:00 Introduction 01:07 Global risk of dengue 06:02 Arboviral diseases in the Americas Region 08:32 Dengue Virus 09:46 Main vectors of DENV 11:43 Pathogenesis of severe dengue 15:00 Immunopathogenesis of severe dengue in secondary infections 17:25 Reduced risk of disease during postsecondary Dengue Virus infections 20:15 Antibody-dependent enhancement of severe dengue 22:54 Clinical presentation of dengue 26:14 Disease course of severe dengue 29:05 New classification of dengue 30:17 Warning signs of dengue 33:03 Severe dengue 34:42 Laboratory changes according to dengue phases 38:51 Level of NS1, IgM and IgG for primary and secondary dengue infection 42:30 Key points This podcast was partially sponsored through a medical educational grant by Takeda.