immunology – Global Health Press

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Human pertussis challenge study identifies plausible correlates of protection—but only in a whole-cell-primed generation

Summary Two Lancet Microbe papers together present and contextualize a controlled human infection model for Bordetella pertussis in healthy adults. The primary study showed that outpatient intranasal challenge with CFU...

22 July, 2026

2 min read

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Needle-free pan-sarbecovirus vaccine clears phase 1 safety milestone, but broad protection remains unproven

Summary This open-label, first-in-human phase 1 dose-escalation trial evaluated the DNA vaccine pEVAC-PS, a computationally designed pan-sarbecovirus candidate delivered intradermally by needle-free PharmaJet Tropis in...

21 July, 2026

2 min read

GHP News Latest Science

Old epilepsy drug repurposed as a low-cost metabolic vaccine booster increases T-cell responses 10-fold in a human trial

Summary A multiomic screen matched T-cell memory transcriptional signatures against >30,000 drug perturbation profiles, identifying lysine deacetylase inhibitors (KDACi) as candidate immunometabolic adjuvants. Low...

21 July, 2026

2 min read

GHP News Latest Science

Game-changer in immunology:
T-cells proven to prevent viral infections without antibodies

T cells can independently prevent viral infections, challenging the dominance of antibodies in vaccine design. Future vaccines should aim to stimulate both T-cell and antibody responses for broader protection. Further...

14 January, 2025

3 min read

Jan 2025 VacciReview

Neuraminidase-based inactivated influenza vaccine demonstrates significant protection in swine

References Kaplan BS, Souza CK, Kimble JB, et al. A neuraminidase-based inactivated influenza virus vaccine significantly reduced virus replication and pathology following homologous...

2 January, 2025

2 min read

Tag - immunology

Human pertussis challenge study identifies plausible correlates of protection—but only in a whole-cell-primed generation

Needle-free pan-sarbecovirus vaccine clears phase 1 safety milestone, but broad protection remains unproven

Old epilepsy drug repurposed as a low-cost metabolic vaccine booster increases T-cell responses 10-fold in a human trial

Game-changer in immunology:T-cells proven to prevent viral infections without antibodies

Neuraminidase-based inactivated influenza vaccine demonstrates significant protection in swine

Game-changer in immunology:
T-cells proven to prevent viral infections without antibodies