vaccine development – Global Health Press

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Closing the gap: The race for a Bundibugyo Ebola vaccine

Why is there a medical need The outbreak that began in mid-May 2026 in the Democratic Republic of the Congo (DRC), with cross-border spread to Uganda, is caused by Bundibugyo ebolavirus (BDBV) — a species distinct from...

3 September, 2026

10 min read

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The PPP of dengue vaccines: past, present, and pipeline

Background: recent event Brazil’s Ministry of Health has temporarily suspended the Butantan dengue vaccine (Butantan‑DV) as a precaution after a small number of serious suspected adverse events, including two deaths...

23 July, 2026

12 min read

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Human pertussis challenge study identifies plausible correlates of protection—but only in a whole-cell-primed generation

Summary Two Lancet Microbe papers together present and contextualize a controlled human infection model for Bordetella pertussis in healthy adults. The primary study showed that outpatient intranasal challenge with CFU...

22 July, 2026

2 min read

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Old epilepsy drug repurposed as a low-cost metabolic vaccine booster increases T-cell responses 10-fold in a human trial

Summary A multiomic screen matched T-cell memory transcriptional signatures against >30,000 drug perturbation profiles, identifying lysine deacetylase inhibitors (KDACi) as candidate immunometabolic adjuvants. Low...

21 July, 2026

2 min read

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ViVa 28 feature: Universal influenza vaccines – more than just “broader immunity”

Why We Need a Universal Influenza Vaccine Every year, millions of people roll up their sleeves for a flu shot, and every year, that same shot needs reformulating. This isn’t bureaucratic inefficiency — it’s...

15 July, 2026

5 min read

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ViVa News — Week 28

Shigella vaccine breakthrough The live-attenuated oral Shigella sonnei vaccine WRSs2 reported 89% efficacy against shigellosis in a phase 2 controlled human infection trial — the highest protection rate ever recorded...

15 July, 2026

2 min read

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Literature update ViVa week 28-2026

1. Five years after the global TB vaccine roadmap launched, progress is real but painfully thin This narrative review updates the 2021 Global Roadmap for tuberculosis (TB) vaccine research and development, assessing...

14 July, 2026

10 min read

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Multivalent and Combination Vaccines in 2026: Promise, Immunologic Questions, and HTA Headaches

Combination and multivalent vaccines have always been the backbone of vaccination programs. An interim high appeared in the mid-1990ies when 6-valent DTaP combination vaccines were developed (DTaP-Hib-IPV-HBV)...

1 July, 2026

8 min read

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Ebola Bundibugyo vaccine – current status

The 2026 Bundibugyo ebolavirus outbreak in eastern DR Congo and Uganda has triggered an unprecedented acceleration of vaccine development for a strain that, until now, had no candidates even in Phase 1 trials. As of 22...

24 June, 2026

4 min read

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Literature update ViVa week 24-2026

=1. Mpox joins the mRNA club: BioNTech’s first in-human BNT166a data hint at broad orthopox potential—but neutralizing titers fade fast In this phase 1, first-in-human, open-label dose escalation study, healthy Vaccinia...

18 June, 2026

11 min read

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