Roadmap outlines a framework for moving COVID-19 vaccines forward

In a recent report published in Vaccine, researchers presented the coronavirus vaccines research and development roadmap (CVR) to promote the development of broadly protective coronavirus disease 2019 (COVID-19) vaccines. COVID-19 has caused unprecedented morbidity and mortality worldwide. Broadly cross-protective vaccines must be developed to protect against novel emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants with greater transmissibility, virulence, and immune evasiveness. The vaccines would aid in mitigating the effects of COVID-19 and future viral outbreaks. In the present report, researchers summarized key issues and highlighted research areas outlined in the CVR to develop broadly protective pan-CoV vaccines. Vaccine development to combat COVID-19 and other pandemics Vaccines must be quickly available for mitigating novel coronavirus (CoV) threats, which could be achieved by developing ‘prototype vaccines’ available for initial vaccine authorization and manufacturing at scale within 100 days of recognizing a pandemic threat rather than just-in-time vaccine development. Another approach involves the development of...