Even if measles infection incidence has decreased by at least 90% all over the world since the introduction of the vaccine, measles is still one of the major causes of death in children among vaccine-preventable diseases. Regular measles epidemics are reported in developing countries and recurrent episodic outbreaks occur in the developed world.
A new study by Bocconi University and Bruno Kessler Foundation analyzing nine countries (Australia, Ethiopia, Kenya, Ireland, Italy, South Korea, Singapore, the UK, the US) and published in The Lancet Infectious Diseases, highlights the role played by demographics in the spread of measles and concludes that future vaccination strategies in high-fertility countries should focus on increasing childhood immunization rates, while immunization campaigns targeting adolescents and young adults are required in low fertility countries.
Using a transmission model calibrated on historical serological data the authors estimate that the susceptible proportion of the population (i.e. unprotected against the infection) varies from approx. 3% in the UK to more that 12,5% in Ethiopia, with astonishing differences in its age-composition, due to different vaccination strategies and divergent demographic trends. While the percentage of over-15 among susceptible individuals in Ethiopia and Kenya is, respectively, 28% and 43%, adolescents and young adults represent 74% of unprotected individuals in South Korea, 66% in Italy and 53% in the US, with considerable immunity gaps in individuals aged 30-40 years.
“Every effort to increase the vaccination coverage rate among children is praiseworthy”, says Alessia Melegaro, a Bocconi professor and principal investigator of DECIDE, the ERC-funded project which produced the article, “but in some developed countries it’s the lack of coverage among adolescents and adults that poses a serious threat to the goal of eliminating measles.”
The proposed model shows that the introduction of the measles vaccine, which occurred at different times in the nine countries, has considerably reduced the disease burden in terms of disability-adjusted life-years (DALYs), a measure expressed as the number of years lost because of illness, disability, or early death. Every vaccine dose averts two or three weeks of DALYs in the developed world and around 20 weeks in Kenya and Ethiopia. Which translates into 2-mln years since the vaccine introduction in the UK, 13-mln in the US and 36-mln in Ethiopia.
“Vaccination has undoubtedly achieved incredible results in terms of public health. In particular,” continues Prof. Melegaro “our analysis showed that routine first dose vaccine administration has been responsible for more than 90% of the overall number of vaccine-immunized individuals in most countries. In Ethiopia and Kenya, catch-up and follow-up campaigns substantially mitigated the effect of suboptimum routine vaccine coverage, generating 25-45% of the immunized fraction of the population. Tailoring immunization campaigns to achieve measles eradication goals is essential and currently, for some countries, this means considering also the role of unprotected adolescents and young adults”.
Source: Università Bocconi