Baseline cytokine levels influence antibody responses to pertussis booster vaccination in finnish cohorts

References Anabe D, Teräsjärvi JT, Barkoff AM, et al. Association of baseline cytokines with antibody concentrations after diphtheria-tetanus-acellular pertussis booster vaccination in Finnish children. Vaccine. 2025;44:126573. doi:10.1016/j.vaccine.2024.126573 Summary This study investigates the relationship between baseline cytokine concentrations and antibody responses following diphtheria-tetanus-acellular pertussis (Tdap) booster vaccination in Finnish children, adolescents, young adults, and older adults. The research focuses on understanding how pre-existing immune factors, particularly cytokines, impact vaccine efficacy. The study involved 124 participants across four age groups (7–70 years), who received the Tdap3-IPV booster. Baseline levels of cytokines such as IFN-γ, IL-2, IL-5, IL-10, IL-13, IL-17A, and IL-17F were measured. Antibody concentrations against pertussis toxin (PT), filamentous hemagglutinin (FHA), pertactin (Prn), diphtheria toxoid (DT), and tetanus toxoid (TT) were assessed before vaccination and at one month and one-year post-vaccination. Statistical analyses included mixed models to explore associations between cytokine levels and antibody responses: Age-Dependent Cytokine Profiles: Children had higher proportions of detectable cytokines (e.g.,...