Overview
- Maternal vaccination is a core component of life-course immunization and provides passive antibody protection to infants during the first six months of life through transplacental transfer.
- The guide outlines recommended vaccines during pregnancy—Influenza, COVID-19, Tdap (27–36 weeks), and RSV (24–36 weeks, subject to local approval)—with defined gestational timing.
- Vaccination during pregnancy significantly reduces severe disease and hospitalization risk in both mothers and infants, including up to 91% protection against pertussis and substantial reductions in influenza, RSV, and COVID-19–related hospitalizations.
- Large safety studies show no increased risk of miscarriage, stillbirth, preterm birth, low birth weight, birth defects, or NICU admission associated with recommended maternal vaccines.
- Clinical decision-making should be individualized, with pregnant women advised to consult healthcare providers to ensure optimal timing and alignment with national recommendations.
