1. Dengue antibodies play both hero and villain — and severity may tip the scales Vietnamese pediatric data show that the same antibody surge protecting children from repeat dengue may also be quietly loading the gun for antibody-dependent enhancement, especially against Zika. Study summary: This observational study analyzed 50 paired acute/convalescent sera from Vietnamese pediatric dengue patients (2015–2017, ages 0–17 years, mean age 8.6 ± 4.2 years; 36% primary, 64% secondary infection) using single round infectious particles to quantify neutralizing (NAb) and antibody-dependent enhancement (ADE) activity against all 4 DENV serotypes, Japanese encephalitis virus (JEV), and Zika virus (ZIKV). NAb titers were highest against DENV-1, rose during convalescence, and were higher in secondary infections and dengue shock syndrome (DSS)cases. ADE was strongest against DENV-2, weakest against DENV-4, and correlated positively with NAb titers (Spearman r = 0.48–0.66). Cross-reactive neutralizing and enhancing responses against JEV and ZIKV were detected, with enhancement notably stronger for...
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