Researchers optimistic about malaria vaccine progress

While the world is as close as it has ever been to having a malaria vaccine, the fight to eradicate the disease is far from over. That was the consensus among experts in the field who gathered at a forum hosted by Harvard’s Defeating Malaria: From the Genes to the Globe initiative on April 6, 2016. Focused on the latest research in vaccine development for infectious diseases, the event highlighted the promise and limitations of RTS,S, the first malaria vaccine candidate to win regulatory approval. Development of RTS,S began in the 1980s at GlaxoSmithKline, which later partnered with international nonprofit PATH on the effort. Recent clinical trials found that the vaccine provided modest immunity for older babies, although that protection waned over time. While its performance has been less than ideal, the burden of malaria is so high—214 million cases each year and 438,000 deaths, primarily in children in Africa, according to...