Dynamics of influenzas vaccine induced antibodies – what can we learn?

Lane A, Quach HQ, Ovsyannikova IG, Kennedy RB, Ross TM, Einav T. High-resolution antibody dynamics following influenza vaccination reveal predominantly weak responses as well as infrequent but durable immunity across the 2014–2022 seasons. Vaccine. 2025. doi:10.1016/j.vaccine.2025.127677 This study by Lane et al. examines the heterogeneity and temporal dynamics of antibody responses to influenza vaccination by conducting two new vaccine studies and analyzing data from twelve prior studies between 2014 and 2022. The authors measured hemagglutination inhibition (HAI) titers against H3N2 and H1N1 strains from the day of vaccination to one year post-vaccination, generating a dataset of more than 1,300 individual antibody trajectories. Findings show that the majority of vaccine recipients, over 50% across all seasons, age groups, sexes, baseline titers, and vaccine types, exhibited weak responses, defined as less than a four-fold rise in HAI titers at both one month and one year. A smaller group demonstrated strong responses, further classified as...