Overview
- Classical vaccine manufacturing is a structured 5-step process that transforms a biological seed into a safe, injectable vaccine.
- It begins with antigen production, where microbes or cells are grown to generate the target antigen.
- The antigen is then harvested and separated from cells and debris using filtration and centrifugation methods.
- For inactivated vaccines, pathogens are rendered non-infectious while preserving their ability to trigger an immune response.
- The product undergoes purification to remove contaminants and ensure high quality and safety.
- In the final step, the antigen is formulated with stabilizers and adjuvants and filled into vials or syringes.
- Throughout the process, strict controls address risks such as contamination, genetic instability, and incomplete inactivation.
- Overall, the goal is to produce a safe, effective, and consistent vaccine ready for use.
