Epidemiology and trends Adenovirus infections remain a significant cause of respiratory and gastrointestinal illness worldwide, especially in infants, young children, immunocompromised individuals, and those with chronic lung or heart disease. Outbreaks have been reported in densely populated regions and places with poor hygiene, and also with notable surges in South Asia and parts of China and India. For example, West Bengal, India, saw over 12,000 confirmed pediatric cases and 150 related deaths in early 2023. Infections can occur year-round, but are most common in late winter, spring, and early summer. Clinical features Symptoms: Adenovirus infections typically present as mild cold or flu-like symptoms (sore throat, cough, fever, runny nose), but can also cause conjunctivitis (pink eye), bronchitis, pneumonia, gastroenteritis, and, rarely, severe complications such as myocarditis or encephalitis. Duration: Most infections last 3–7 days, but severe cases can persist for weeks, especially in vulnerable groups. Severity predictors: Severe cases are more likely in younger children, those with dyspnea, decreased activity, pneumonia,...
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