Hepatitis A vaccines manufactured and licensed in China

The live attenuated hepatitis A vaccines developed and used in China are primarily based on two strains: H2 and LA-1. These vaccines are distributed under several brand names: H2 strain: Weisairuiji (also spelled Weisa Airuiji), BIOVAC-A, MEVAC-A; MAH: Institute of Medical Biology, Chinese Academy of Medical Sciences, Kunming Zhejiang Pukang Biotechnology Company Limited, Zhejiang Academy of Medical Sciences, Hangzhou LA-1 strain: HAVAC MAH: Changchun Institute of Biological Products and Changchun Changsheng Life Sciences Limited Both vaccines are provided as freeze-dried formulations for subcutaneous injection and are approved for use in China’s national immunization program. The H2 strain vaccine is also licensed in India for private use. Live attenuated hepatitis A vaccines are a unique product developed, licensed, and widely used in China. Both strains—H2 and LA-1—were developed through serial passage of wild-type HAV in cell cultures, resulting in attenuation. These vaccines are administered as a single subcutaneous dose, typically at 18 months of age, and have been integrated into...